Noninvasive fetal sex determination in maternal plasma: a prospective feasibility study

Prenatal determination of farm animal fetal sex using free fetal DNA in maternal plasma

In many farm animal species, the preference of a specific sex is obvious mainly due to commercial implications; so for comprehensive and efficient results in the livestock management plans specially breedingand selection programs, it is necessary to include acost-effective and reliable strategy for early determination of fetal sex. Several invasive and non-invasive approaches have been establis...

Noninvasive detection of a balanced fetal translocation from maternal plasma.

BACKGROUND Massively parallel sequencing of circulating cell free (ccf) DNA from maternal plasma has been demonstrated to be a powerful method for the detection of fetal copy number variations (CNVs). Although the detection of CNVs has been described by multiple independent groups, genomic aberrations resulting in copy number-neutral events including balanced translocations have proven to be mo...

Noninvasive fetal whole-genome sequencing from maternal plasma: feasibility studies and future directions.

The discovery of cell-free fetal DNA in maternal plasma in 1997 has catalyzed the development of noninvasive prenatal diagnosis (1 ). Fetal DNA represents on average approximately 15% of the total circulating DNA in maternal plasma. The advent of massively parallel sequencing has made possible the analysis of circulating fetal DNA with unprecedented precision. In 2010, Lo et al. demonstrated th...

A Low-Cost Efficient Multiplex P CR for Prenatal Sex Determination in Bovine Fetus U sing Free Fetal DNA in Maternal Plasma

noninvasive prenatal test by cell-free fetal dna in maternal plasma: current progress and prospective clinical applications

context prenatal testing aims to identify fetal chromosomal and genetic disorders prior to delivery. current invasive procedures such as amniocentesis and chorionic villus sampling (cvs) pose a risk to mother and fetus and such diagnostic procedures are available only to high-risk pregnancies, which limits aneuploidy detection rate. the identification of cell-free fetal dna (cffdna) in maternal ...